Comparing Antibodies & Small Molecules to Best Address Immunogenicity, Biodistribution & Efficacy in Drug Development
12:00 pm - Thursday 28th January 2027
- Comparing the molecular and pharmacological properties of antibodies and small molecules to understand how size, affinity, valency and molecular architecture influence target engagement and therapeutic performance
- Exploring how modality choice impacts biodistribution, tissue penetration, dosing and productive intracellular delivery, while considering modality-specific challenges including immunogenicity and off-target exposure
- Using preclinical and clinical examples to define where antibodies and small molecules offer distinct advantages, providing a practical framework for selecting the right targeting modality for the target, tissue and therapeutic payload
